Oct 18, 2021
In this “Ask Me Anything” (AMA)
episode, Peter and Bob discuss all things related to testosterone:
what happens when testosterone levels are low, and the potential
benefits and risks of testosterone replacement therapy (TRT). They
explain the physiology of testosterone, how it works, and how its
level changes over the course of a person's life. They have a
detailed discussion about existing literature, which reveals vast
potential structural, functional, and metabolic benefits of
testosterone replacement therapy. They also take a very close look
at potential risks of this therapy, with a focus on the
controversial effects on cardiovascular disease and prostate
cancer.
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benefits here.
We
discuss:
- A primer on
the hormone testosterone and how it influences
gene expression [3:30];
- How the body naturally regulates
testosterone levels [11:30];
- The defining threshold for "low
testosterone," how low T impacts men, and why free
testosterone is the most important metric
[16:15];
- When it makes sense to treat low
testosterone [26:00];
- The structural and metabolic
benefits of testosterone replacement therapy
[29:15];
- Body composition changes
with TRT [45:30];
- Changes in bone mineral density
with TRT [48:15];
- The metabolic impact of TRT:
glucose, insulin, triglycerides, and more
[52:30];
- A study investigating testosterone
replacement therapy for prevention or reversal of type 2
diabetes [59:30];
- The impact of TRT on metabolic parameters and body composition—A study comparing results from continuous vs. interrupted treatment [1:07:15]
- The controversy
over TRT and cardiovascular disease
[1:21:45];
- Two flawed studies that shaped
perceptions of risks associated
with TRT [1:44:15];
- The controversy
over TRT and prostate cancer
[1:56:45];
- Other potential risks with
testosterone replacement therapy [2:02:15]; and
- More
Show notes page for this episode: https://peterattiamd.com/ama28/
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