Dec 17, 2018
In this episode, Dr. Rudy Leibel, an expert in Clinical
Molecular Genetics and Genomics at Columbia University, discusses
his role in the remarkable scientific story of discovering leptin.
He also gets into the genetics of obesity, as well as a broader
discussion of the causes and effects of obesity, energy
expenditure, and metabolism.
- Rudy’s background, interest in obesity, and trying to
understand the role and impact of adipose tissue [4:15];
- Finding the first evidence of leptin by studying obese mice
- Zucker rats, and the push/pull theories of obesity
- A breakthrough in obesity research, and closing in on leptin
- Understanding leptin in humans [1:03:30];
- What Prader–Willi syndrome teaches us about body weight
- Leptin and the broad condition of obesity, metabolic
consequences of weight reduction, and Peter’s self-experiments
- How is appetite being regulated? [1:29:45];
- Are there epigenetic consequences of being obese?
- What makes low-carb diets so effective at obesity reduction?
- What did Rudy believe 10 years ago that he no longer believes
to be true? [1:55:15];
- Rudy’s dream study of the FTO gene [1:57:15];
- What the hell does insulin resistance actually mean? [2:08:30];
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